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Synthetic vs. Bio-Identical Hormone Replacement

This study that shows a difference between synthetic (estrogen-progestin) and Bio-Identical (estrogen-progesterone) hormone replacement therapy.  This study demonstrated no risk of breast cancer from progesterone (bio-identical) use. Furthermore, this study also shows that progestins (synthetic) were associated with a significant increase in breast cancer. Breast Cancer Res. Treat. 2007; Vol.:125-134.

“HRT after treatment of breast cancer has not been demonstrated to increase risk of recurrence or mortality.” J of Obstet Gynecol 2004 Jan; 23(1):49-60.

“Progestins (synthetic) increase proliferation of breast tissue.  A new study shows that progesterone (bio-identical) has the opposite effect.  Proegesterone was shown to not have any detrimental effect on breast tissues.” J of Steriod Biochem Mol Biol May 2005; (PubMed).

“Progesterone (bio-identical) inhibits human breast cancer cell growth through transitional up-regulation of kinase inhibitor gene.” FEBS LETT 2005 Oct. 24; 579(25)5535-41.

“Despite decades of research, there is no compelling evidence that testosterone has a causative role in prostate cancer.  There is no compelling evidence at present to suggest that high testosterone levels or testosterone administration increases the risk of cancer.” New England Journal of Medicine 2004; 350:482-92.

“Testosterone administration to men with PIN (pre-cancer stage) did not go on to further develop prostate cancer.” J of Urol. 2003; 170:2348-51.

“Testosterone increases bone density in women.  Testosterone protects against heart disease in women.” Journal of Reproductive Medicine 1999; 44(12):1012-20.

The complete list of over 140 peer-reviewed studies can be found in Dr. Neal Rouzier’s book, “How to Achieve Healthy Aging,” available for purchase at The Feng Clinic.

American Journal of Public Health | July 2013
Mortality Toll of Estrogen Avoidance

British Medical Journal | October 2012
The Effect of Hormone Replacement Therapy on Cardiovascular Events in Postmenopausal Women: Randomized Trial

Aging Journal | June 2012
Beyond Average: Potential for Measurement of Short Telomeres

Journal of the American Medical Association | April 2011
Health Outcomes After Stopping Estrogen Therapy

The Bioidentical Hormone Debate | January 2009
Postgraduate Medicine

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